西亚试剂：Human Fetal Auditory Stem Cells (hFASCs) Can Be Expanded In

发布时间：2025-05-18

Human Fetal Auditory Stem Cells (hFASCs) Can Be Expanded In Vitro And Differentiate Into Functional Auditory Neurons And Hair Cell-Like Cells

Wei Chen 1 2, Stuart L. Johnson 2, Walter Marcotti 2, Peter W. Andrews 1 2, Harry D. Moore 1 2, Marcelo N. Rivolta 1 2 *§

1Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, United Kingdom
2Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom

In the quest to develop the tools necessary for a cell-based therapy for deafness, a critical step is to identify a suitable stem cell population. Moreover, the lack of a self-renovating model system for the study of cell fate determination in the human cochlea has impaired our understanding of the molecular events involved in normal human auditory development. We describe here the identification and isolation of a population of SOX2+OCT4+ human auditory stem cells from 9-11 week-old fetal cochleae (hFASCs). These cells underwent long-term expansion in vitro and retained their capacity to differentiate into sensory hair cells and neurons, whose functional and electrophysiological properties closely resembled their in vivo counterparts during development. hFASCs, and the differentiating protocols defined here, could be used to study developing human cochlear neurons and hair cells, as models for drug screening and toxicity and may facilitate the development of cell-based therapies for deafness.

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