西亚试剂：Substrate Selectivity APPLies to Akt

发布时间：2025-10-27

Substrate Selectivity APPLies to Akt
Shimin Zhao1 and Kun-Liang Guan2,

1 Laboratory of Molecular and Cellular Biology, Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
2 Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA

Summary
The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al., 2008 demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development

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