西亚试剂：Bmp6 Expression Can Be Regulated Independently of Liver Iro

发布时间：2025-11-19

Bmp6 Expression Can Be Regulated Independently of Liver Iron in Mice

Zhang Z， Guo X， Herrera C， Tao Y， Wu Q， et al.

The liver is the primary organ for storing iron and plays a central role in the regulation of body iron levels by secretion of the hormone Hamp1. Although many factors modulate Hamp1 expression， their regulatory mechanisms are poorly understood. Here， we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression. Despite liver iron overload， expression of bone morphogenetic protein 6 (Bmp6)， a potent-stimulator of Hamp1 expression that is expressed under iron-loaded conditions， was decreased. We hypothesized that factors other than liver iron must play a role in controlling Bmp6 expression. Our results show that erythropoietin and Tf-bound iron do not underlie the down-regulation of Bmp6 in our mice models. Moreover， Bmp6 was down-regulated under conditions of high iron demand， irrespective of the presence of anemia. We therefore inferred that the signals were driven by high iron demand. Furthermore， we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression， and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression. Together， these results are consistent with novel mechanisms for regulating Bmp6 and Hamp1 expression.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如溴化汞硝酸亚汞氯化亚汞乙酸苯汞氯化钾汞 碘化汞钾硫氰酸汞硫酸亚汞氧化汞氯化汞碘化汞硝酸汞三氯氧磷三氯化磷碘甲烷二碘甲烷三碘甲烷三氟碘甲烷氘代碘甲烷碘乙烷1,2-二碘乙烷甲酸铷碘化铷溴化铷铬酸铷硫酸铷氟化铷硝酸铷氯化铷碳酸铷硫酸镱 碳酸镱氯化镱硝酸镱氧化镱等均有销售.欢迎订购

上一篇：西亚试剂：5-甲基烟酰氨
下一篇：烟酰胺核糖有助防衰老