EGFR in Limbo

Michael J. Eckl. William C. Hahn.

The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shanet al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenicmutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.

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