西亚试剂：Establishment of Induced Pluripotent Stem Cells from Centen

发布时间：2025-12-10

Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research

Takuya Yagi1, Arifumi Kosakai1, Daisuke Ito1*, Yohei Okada2,3, Wado Akamatsu2, Yoshihiro Nihei1, Akira Nabetani4, Fuyuki Ishikawa4, Yasumichi Arai5, Nobuyoshi Hirose2, Hideyuki Okano2, Norihiro Suzuki1

Induced pluripotent stem cell (iPSC) technology can be used to model human disorders, create cell-based models of human diseases, including neurodegenerative diseases, and in establishing therapeutic strategies. To detect subtle cellular abnormalities associated with common late-onset disease in iPSCs, valid control iPSCs derived from healthy donors free of serious late-onset diseases are necessary. Here, we report the generation of iPSCs from fibroblasts obtained immediately postmortem from centenarian donors (106- and 109-years-old) who were extremely healthy until an advanced age. The iPSCs were generated using a conventional method involving OCT4, SOX2, KLF4, and c-MYC, and then differentiated into neuronal cells using a neurosphere method. The expression of molecules that play critical roles in late-onset neurodegenerative diseases by neurons differentiated from the centenarian-iPSCs was compared to that of neurons differentiated from iPSCs derived from familial Alzheimer's disease and familial Parkinson's disease (PARK4: triplication of the α synuclein gene) patients. The results indicated that our series of iPSCs would be useful in neurodegeneration research. The iPSCs we describe, which were derived from donors with exceptional longevity who were presumed to have no serious disease risk factors, would be useful in longevity research and as valid super-controls for use in studies of various late-onset diseases.

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