Autoregulation of microRNA biogenesis by let-7 and Argonaute

Dimitrios G. Zisoulis Zoya S. Kai Roger K. Chang Amy E. Pasquinelli

MicroRNAs (miRNAs) comprise a large family of small RNA molecules that post-transcriptionally regulate gene expression in many biological pathways1. Most miRNAs are derived from long primary transcripts that undergo processing by Drosha to produce ~65-nucleotide precursors that are then cleaved by Dicer, resulting in the mature 22-nucleotide forms2, 3. Serving…

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