西亚试剂：Blood is a cell source that can be easily obtained

发布时间：2025-12-21

Blood is a cell source that can be easily obtained from patients. Mouse B and T cells are amenable to reprogramming by overexpressing Oct4, Sox2, Klf4, and Myc with the ectopic expression of Cepbα and p53 knockdown, respectively (Hanna et al., 2008,Hong et al., 2009). iPSC lines have also been generated from mouse bone marrow progenitor cells (Okabe et al., 2009). We have previously reprogrammed cytokine-mobilized human CD34+ peripheral blood cells to pluripotency, but such harvests are cumbersome, expensive, and time consuming (Loh et al., 2009). Several recent studies reported the generation of iPSCs from human bone marrow and cord blood (Ye et al., 2009,Giorgetti et al., 2009,Haase et al., 2009), but bone marrow harvesting is an invasive procedure, and cord blood is available for only a minority of individuals who have their samples banked at birth. A recent study with peripheral blood from donors with myeloproliferative disorder (MPD) isolated iPSC colonies that contain the JAK2-V617F mutation (Ye et al., 2009), but MPD is characterized by abnormally high numbers of circulating CD34+ cells from the bone marrow. These previous studies demonstrating successful reprogramming of blood cells into iPSCs have relied on specialized blood cell sources with high proliferative potential.

 

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