西亚试剂：Selection at Linked Sites Shapes Heritable Phenotypic Varia

发布时间：2025-12-22

Selection at Linked Sites Shapes Heritable Phenotypic Variation in C. elegans
Matthew V. Rockman,1,2,* Sonja S. Skrovanek,2,3 Leonid Kruglyak2,3,*

Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, whereas mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTLs) influencing transcript abundance traits in a cross of two Caenorhabditis elegans strains; although trait-specific mutation and selection explained some of the observed pattern of QTL distribution, the pattern was better explained by trait-independent variation in the intensity of selection on linked sites. Our results suggest that traits in C. elegans exhibit different levels of variation less because of their own attributes than because of differences in the effective population sizes of the genomic regions harboring their underlying loci.

1 Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.
2 Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA.
3 Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA

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