西亚试剂：miR-142-3p regulates the formation and differentiation of h

发布时间：2026-01-01

miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates

Xinyan Lu1，*， Xiajuan Li1，*， Qiuping He1， Jiao Gao2， Ya Gao1， Bing Liu2 and Feng Liu1

Previous studies on developmental hematopoiesis have mainly focused on signaling and transcription factors， while the appreciation of epigenetic regulation including that of microRNAs is recent. Here， we show that in zebrafish and mouse， miR-142-3p is specifically expressed in hematopoietic stem cells (HSCs). Knockdown of miR-142a-3p in zebrafish led to a reduced population of HSCs in the aorta-gonad-mesonephros (AGM) region as well as T-cell defects in the thymus. Mechanistically， miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling. Finally， we show that miR-142-3p is also involved in the development of HSCs in mouse AGM， suggesting that it has a highly conserved role in vertebrates. Together， these findings unveil the pivotal roles that miR-142a-3p plays in the formation and differentiation of HSCs by repressing irf7 signaling.

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