西亚试剂：Age-related changes of germline stem cell activity, niche s

发布时间：2025-05-26

OnlineAccepted Articles (Accepted, unedited articles or abstracts published online for future issues)

To cite this article: Rui Zhao, Yang Xuan, Xinghua Li, Rongwen Xi (2008)
Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila
doi:10.1111/j.1474-9726.2008.00379.x
(Online Accepted)

Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila
Rui Zhao, Yang Xuan, Xinghua Li & Rongwen Xi**corresponding author: National Institute of Biological Sciences No. 7 Science Park Road Zhongguancun Life Science Park Beijing 102206, China Tel: 86-10-80723241 Fax: 86-10-80723249 E-mail: National Institute of Biological Sciences (NIBS), Beijing 102206, China
*corresponding author: National Institute of Biological Sciences No. 7 Science Park Road Zhongguancun Life Science Park Beijing 102206, China Tel: 86-10-80723241 Fax: 86-10-80723249 E-mail: Summary

Adult stem cells are important in replenishing aged cells to maintain tissue homeostasis. Aging in turn may exert profound effects on stem cell’s regenerative potential, but to date the mechanisms of such stem cell aging are poorly understood, and it is not clear to what extent stem cell aging contributes to tissue or organ aging. Here we show in female Drosophila, that germline stem cell (GSC) division rate progressively declines with age, which is accompanied by reduced decapentaplegic (dpp) niche signaling pathway activation within GSCs. Egg production also rapidly declines with age, which is accompanied by both decreased stem cell division and increased incidence of cell death of developing eggs, especially in the oldest females. Genetically increasing dpp expression delays GSC activity decline and transiently increases egg production. We conclude that age-related decline of reproduction is caused by both decreased GSC activity and increased incidence of cell death during oogenesis, while decreased GSC activity is attributed to declined signaling from the regulatory niche. We suggest that niche functional decay may be an important mechanism for stem cell aging and system failure.

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