西亚试剂：大脑发育与脑功能的分子和细胞机制

发布时间：2026-01-17

大脑发育与脑功能的分子和细胞机制。大脑是生物体内最复杂的器官之一，而这一复杂系统是由胚胎发育早期的神经干细胞发育分化而来的。因此，研究神经干细胞发生和神经元发育分化的分子机制，将有助于加深人们对大脑是如何形成的这一问题的认识。同时，在分子水平上研究脑重要功能相关基因，将有助于加深人们对大脑是如何工作的这一问题的认识。 


目前从事的主要研究工作有：
1. 以胚胎干细胞（ES）和多潜能P19细胞的体外神经分化为模型，研究多潜能干细胞神经命运决定过程中FGF、BMP和WNT信号通路间的调控网络。 

2. 以鸡胚神经发育为模型，研究在神经发生过程中神经元和胶质细胞命运决定的分子机制。 

3. 小鼠巢蛋白基因表达调控的分子机制。
4. 脑功能及神经系统疾病相关基因的筛选、鉴定及功能研究。 

　

近期发表的研究论文： 

1. X. Gao, W. Bian, J. Yang, K. Tang, H. Kitani, T. Atsumi, N. Jing*. A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells. Biochem. Biophy. Res. Commun., 2001, 284:1098-1103. 

2. Tang K, Yang J, Gao X, Wang C, Liu L, Kitani H, Atsumi T, Jing N*.Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells. Biochem. Biophys. Res. Commun., 2002, 293:167-73. 

3. Lin W, Furthauer M, Thisse B, Thisse C, Jing N, Ang SL. Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Mech. Dev., 2002, 113:163-168. 

4. Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N*. Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639. Eur. J. Neurosci., 2003, 18:102-108. 

5. Shinya Tanaka, Yusuke Kamachi, Aki Tanouchi, Hiroshi Hamada, Naihe Jing and Hisato Kondoh. Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells. Mol. Cell. Biol., 2004, 24:8834-8846. 

6. Qiuling Hou, Xiang Gao, Xuehan Zhang, Linwei Kong, Xinming Wang, Wei Bian, Yanyang Tu, Meilei Jin , Guoping Zhao, Baoming Li, Naihe Jing* and Lei Yu. SNAP -25 in hippocampal CA1 region is involved in memory consolidation. Eur. J. Neurosci., 2004, 20:1593-1603. (Also see: Eur. J. Neurosci., 2004, 20:2489). 

7. Ye Yan, Wei Bain, Zhiqin Xie, Xinmin Cao, Isabelle Le Roux, Francois Guillemot, Naihe Jing*. Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates. Dev. Dyn., 2004, 231:248–257. 

8. Leping Cheng, Zhigang Jin, Li Liu, Ye Yan, Tingting Li, Xueliang Zhu, Naihe Jing*. Characterization and promoter analysis of the mouse nestin gene. FEBS Lett., 2004, 565:195–202. 

9. Jie An, Quan Yuan, Chen Wang, Li Liu, Ke Tang, Hongyu Tian, Naihe Jing* and Fukun Zhao. Differential display of proteins involved in the neural differentiation of mouse embryonic carcinoma P19 cells by comparative proteomic analysis. Proteomics, 2005, 5:1656–1668. 

10. Lirong Diao, Bianhong Zhang, Junkai Fan, Xiang Gao, Shaogang Sun, Kai Yang, Dan Xin, Naihe Jing, Yunqi Geng and Chen Wang. Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκB-ubiquitination. Cell. Signal., 2005, 17:217–229. 

11. Hideki Kanaya, Ryu Takeya, Kosei Takeuchi, Norinobu Watanabe, Naihe Jing and Hideki Sumimoto . Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. Genes to Cells, 2005, 10:665-678. 

12. Xue-Han Zhang ,Hui Zhang, Yanyang Tu, Xiang Gao, Changfu Zhou, Meilei Jin , Guoping Zhao, Naihe Jing*, Bao-Ming Li ,Lei Yu. Identification of a novel protein for memory regulation in the hippocampus. Biochem. Biophy. Res. Commun., 2005, 334:418-424. 

13. Xidao Wang, Yuqiu Zhang, Lingwei Kong, Zhiqin Xie, Zhixin Lin, Ning Guo, Judith A. Strong, Johanna T. A. Meij, Zhiqi Zhao, Naihe Jing* and Lei Yu. RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour. Eur. J. Neurosci., 2005, 22:1090–1096.

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