西亚试剂：TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and M

发布时间：2026-01-17

TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells

Norimoto Kobayashi,1 Piia Karisola,2 Victor Peña-Cruz,1 David M. Dorfman,3 Masahisa Jinushi,1 Sarah E. Umetsu,4 Manish J. Butte,5 Haruo Nagumo,1 Irene Chernova,1 Baogong Zhu,1 Arlene H. Sharpe,5 Susumu Ito,6 Glenn Dranoff,1 Gerardo G. Kaplan,7 Jose M. Casasnovas,8 Dale T. Umetsu,2 Rosemarie H. DeKruyff,2 and Gordon J. Freeman1,

1 Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
2 Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
3 Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
4 Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, Harvard Medical School, Boston, MA 02115, USA
5 Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
6 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
7 Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
8 Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain

Corresponding author
Gordon J. Freeman
Summary

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested. TIM-4+ peritoneal macrophages, TIM-1+ kidney cells, and TIM-4- or TIM-1-transfected cells efficiently phagocytosed apoptotic cells, and phagocytosis could be blocked by TIM-4 or TIM-1 monoclonal antibodies. Mutations in the unique cavity of TIM-4 eliminated PS binding and phagocytosis. TIM-4 mAbs that blocked PS binding and phagocytosis mapped to epitopes in this binding cavity. These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购

 

 

上一篇：西亚试剂：亲近者注意！癌细胞具一定传染性
下一篇：云天化前三季度净利增长超六成