西亚试剂：Direct reprogramming of somatic cells is promoted by matern

发布时间：2026-01-21

Direct reprogramming of somatic cells is promoted by maternal transcriptionfactor Glis1

Momoko Maekawa; Kei Yamaguchi; Tomonori Nakamura; Ran Shibukawa; Ikumi Kodanaka; Tomoko Ichisaka; Yoshifumi Kawamura; Hiromi Mochizuki; Naoki Goshima; Shinya Yamanaka

Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transgenic expression of three transcription factors collectively called OSK: Oct3/4 (also called Pou5f1), Sox2 and Klf41. However, the conversion to iPSCs is inefficient. The proto-oncogene Myc enhances the efficiency of iPSC generation by OSK but it also increases the tumorigenicity of the resulting iPSCs2. Here we show that the Gli-like transcription factor Glis1 (Glis family zinc finger 1) markedly enhances the generation of iPSCs from both mouse and human fibroblasts when it is expressed together with OSK. Mouse iPSCs generated using this combination of transcription factors can form germline-competent chimaeras. Glis1 is enriched in unfertilized oocytes and in embryos at the one-cell stage. DNA microarray analyses show that Glis1 promotes multiple pro-reprogramming pathways, including Myc, Nanog, Lin28, Wnt, Essrb and the mesenchymal–epithelial transition. These results therefore show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation.

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