西亚试剂：Integrative analysis of haplotype-resolved epigenomes acros

发布时间：2026-01-23

Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy1. The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.

以上资料由西亚试剂：http://www.xiyashiji.com/ 提供

上一篇：西亚试剂:《科学》预测2015年重要突破
下一篇：西亚试剂:农业科学大豆吸胀前后籽粒外形指标的变化