西亚试剂：Mesenchymal stem cells prevent restraint stress-induced lym

发布时间：2026-01-28

Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4

Gang Caoa， Qian Yanga， Siyu Zhanga， Chunliang Xua， Arthur I. Robertsb， Ying Wanga， Yufang Shia， b

Chronic stress has dramatic impacts on the immune system and consequently contributes to the onset and progression of a variety of diseases， including cancer， immune disorders， and infections. Recent studies in animals and humans have demonstrated that mesenchymal stem cells (MSCs) significantly modulate the immune system. Here we show that administration of MSCs in vivo prevents lymphocyte depletion induced by physical restraint stress (12：12-h stress–rest， 2 repetitions) in mice. This effect was found to be exerted not through modulation of glucocorticoid levels in the circulation， but rather through direct effects on lymphocyte apoptosis. By testing various possible protective mechanisms， we found that IL-4 provides a strong anti-apoptosis signal to lymphocytes in the presence of dexamethasone. When neutralizing antibody against IL-4 was co-administered with MSCs to restraint-stressed mice， the protective effect of MSCs was diminished. Furthermore， in mice deficient in STAT6， a key molecule in IL-4 receptor-mediated signaling， MSCs had no effect on restraint stress-induced lymphocyte depletion. Additionally， MSCs administered to stressed mice promoted IL-4 production by splenocytes. This study reveals that MSCs can effectively prevent stress-induced lymphocyte apoptosis in an IL-4-dependent manner and provides novel information for the development of countermeasures against the deleterious effects of stress on the immune system.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如诺卡氏菌液(-)-樟脑神经鞘磷脂,从牛脑所得 杨梅苷愈创奥IAPN-叔丁基苯硫腈氯化物4-溴苯基五氟化硫色胺盐酸盐4-溴噻吩-2-甲醛纤维素粉 7-(二甲基氨基)-4-三氟甲基香豆素邻硝基苯肼盐酸盐3,3'-二氨基联苯胺四盐酸盐水合物美伐他汀丁卡因阿卡明全氟辛基季胺碘化物布西拉明硫酸多粘菌素B益母草浸膏黄苓干膏 L-2,3-二氨基丙酸盐酸盐黄糊精EB替代品(GoldView)等均有销售.欢迎订购

上一篇：2-噻吩基乙酰腈
下一篇：替诺昔康制法/工艺