西亚试剂：Ryanodine receptor arrays: not just a pretty pattern?

发布时间：2026-02-08

Ryanodine receptor arrays: not just a pretty pattern?

Chang-Cheng Yin1, Leon G. D’Cruz2 and F. Anthony Lai2, 
1Department of Biophysics, Peking University Health Science Centre, and Centre for Protein Science, Peking University, Beijing 10083, China
2Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK
Available online 10 March 2008Available online 10 March 2008

Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to many non-excitable cells. They comprise high-conductance ion channels that mediate the massive release of Ca2+ ions from the endoplasmic reticulum into the cytoplasm. This is the trigger for contraction during each muscle excitation–contraction coupling cycle. Individual RyRs are believed to network with other RyRs indirectly, through diffusion of released Ca2+ ions, namely the Ca2+-induced Ca2+ release phenomenon. However, RyRs can intrinsically organize into a regular array resembling a distinctive checkerboard pattern, with each square-shaped receptor appearing to abut four neighbours at each corner. In this opinion article, we describe recent data showing structural interactions between RyR oligomers in reconstituted arrays, and we suggest that this provides strong evidence for direct inter-RyR communication through a novel, allosteric regulatory mechanism.

 

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