西亚试剂：Interferon modulation of cellular microRNAs as an antiviral

发布时间：2026-02-17

Interferon modulation of cellular microRNAs as an antiviral mechanism

Irene M. Pedersen1, Guofeng Cheng3, Stefan Wieland3, Stefano Volinia4, Carlo M. Croce4, Francis V. Chisari3 & Michael David1,2

Correspondence to: Michael David1,2 Correspondence and requests for materials should be addressed to M.D. (Email: midavid@ucsd.edu).

RNA interference through non-coding microRNAs (s) represents a vital component of the innate antiviral immune response in plants and invertebrate animals; however, a role for cellular miRNAs in the defence against viral infection in mammalian organisms has thus far remained elusive1. Here we show that interferon beta (IFN) rapidly modulates the expression of numerous cellular miRNAs, and that eight of these IFN-induced miRNAs have sequence-predicted targets within the hepatitis C virus (HCV) genomic RNA. The introduction of synthetic miRNA-mimics corresponding to these IFN-induced miRNAs reproduces the antiviral effects of IFN on HCV replication and infection, whereas neutralization of these antiviral miRNAs with anti-miRNAs reduces the antiviral effects of IFN against HCV. In addition, we demonstrate that IFN treatment leads to a significant reduction in the expression of the liver-specific miR-122, an miRNA that has been previously shown to be essential for HCV replication2. Therefore, our findings strongly support the notion that mammalian organisms too, through the interferon system, use cellular miRNAs to combat viral infections.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如溴化汞硝酸亚汞氯化亚汞乙酸苯汞氯化钾汞 碘化汞钾硫氰酸汞硫酸亚汞氧化汞氯化汞碘化汞硝酸汞三氯氧磷三氯化磷碘甲烷二碘甲烷三碘甲烷三氟碘甲烷氘代碘甲烷碘乙烷1,2-二碘乙烷甲酸铷碘化铷溴化铷铬酸铷硫酸铷氟化铷硝酸铷氯化铷碳酸铷硫酸镱 碳酸镱氯化镱硝酸镱氧化镱等均有销售.欢迎订购

上一篇：西亚试剂:2014自然指数揭示中国十大科研领先城市
下一篇：西亚试剂： 乙酸-2-甲基丁酯