西亚试剂：Meiotic chromosome structures constrain and respond to desi

发布时间：2025-05-30

Meiotic chromosome structures constrain and respond to designation of crossover sites

Diana E. Libuda，Satoru Uzawa，Barbara J. Meyer& Anne M. Villeneuve

Crossover recombination events between homologous chromosomes are required to form chiasmata， temporary connections between homologues that ensure their proper segregation at meiosis I1. Despite this requirement for crossovers and an excess of the double-strand DNA breaks that are the initiating events for meiotic recombination， most organisms make very few crossovers per chromosome pair2. Moreover， crossovers tend to inhibit the formation of other crossovers nearby on the same chromosome pair， a poorly understood phenomenon known as crossover interference3， 4. Here we show that the synaptonemal complex， a meiosis-specific structure that assembles between aligned homologous chromosomes， both constrains and is altered by crossover recombination events. Using a cytological marker of crossover sites in Caenorhabditis elegans5， we show that partial depletion of the synaptonemal complex central region proteins attenuates crossover interference， increasing crossovers and reducing the effective distance over which interference operates， indicating that synaptonemal complex proteins limit crossovers. Moreover， we show that crossovers are associated with a local 0.4–0.5-micrometre increase in chromosome axis length. We propose that meiotic crossover regulation operates as a self-limiting system in which meiotic chromosome structures establish an environment that promotes crossover formation， which in turn alters chromosome structure to inhibit other crossovers at additional sites.

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