西亚试剂：Spinster is required for autophagic lysosome reformation an

发布时间：2026-03-04

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

Rong, Yueguang; McPhee, Christina K.; Deng, Shuangshen; Huang, Lei; Chen, Lilian; Liu, Mei; Tracy, Kirsten; Baehrecke, Eric H.; Yu, Li; Lenardo, Michael J.

Autophagy is a conserved cellular process to degrade and recycle cytoplasmic components. During autophagy, lysosomes fusewith an autophagosome to form an autolysosome. Sequestered components are degraded by lysosomal hydrolases and presumablyreleased into the cytosol by lysosomal efflux permeases. Following starvation-induced autophagy, lysosome homeostasis is restoredby autophagic lysosome reformation (ALR) requiring activation of the “target of rapamycin” (TOR) kinase. Spinster (Spin) encodesa putative lysosomal efflux permease with the hallmarks of a sugar transporter. Drosophila spin mutants accumulate lysosomal carbohydrates and enlarged lysosomes. Here we show that defects in spin lead to the accumulation of enlarged autolysosomes. We find that spin is essential for mTOR reactivation and lysosome reformation following prolonged starvation. Further, we demonstrate thatthe sugar transporter activity of Spin is essential for ALR.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购

上一篇：西亚试剂:美国个性化医疗探索：根据病人的DNA进行“定制医疗”？(
下一篇：西亚试剂：药物治疗的新思路----生物节律治疗