西亚试剂：Riboswitches in Eubacteria Sense the Second Messenger Cycli

发布时间：2025-06-16

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

N. Sudarsan,¹ E. R. Lee,² Z. Weinberg,² R. H. Moy,³ J. N. Kim,² K. H. Link,¹ R. R. Breaker^1,2,3*

Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.

¹ Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
² Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
³ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如溴化汞硝酸亚汞氯化亚汞乙酸苯汞氯化钾汞 碘化汞钾硫氰酸汞硫酸亚汞氧化汞氯化汞碘化汞硝酸汞三氯氧磷三氯化磷碘甲烷二碘甲烷三碘甲烷三氟碘甲烷氘代碘甲烷碘乙烷1,2-二碘乙烷甲酸铷碘化铷溴化铷铬酸铷硫酸铷氟化铷硝酸铷氯化铷碳酸铷硫酸镱 碳酸镱氯化镱硝酸镱氧化镱等均有销售.欢迎订购

上一篇：埃克森美孚美国贝城烯烃工厂发生火灾
下一篇：西亚试剂：我国学者在CRISPR/Cas9中取得新进展