西亚试剂：Origin and Evolution of the Eukaryotic SSU Processome Revea

发布时间：2025-06-18

Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus

Jin-Mei Feng1，2， Hai-Feng Tian1，2 and Jian-Fan Wen1，*

As a nucleolar complex for small-subunit ribosomal RNA processing， small-subunit (SSU) processome has been extensively studied mainly in Saccharomyces cerevisiae， but not in diverse organisms， leaving open the questions of whether it is a ubiquitous mechanism across eukaryotes and how it evolved in the course of the evolution of eukaryotes. Genome-wide survey and identification of SSU processome components showed that the majority of all the 77 yeast SSU processome proteins possess homologs in almost all of the main eukaryotic lineages， and 14 of them have homologs in archaea but few in bacteria， suggesting that the complex is ubiquitous in eukaryotes， and its evolutionary history began with abundant protein homologues being present in archaea and then a fairly complete form of the complex emerged in the last eukaryotic common ancestor (LECA). Phylogenetic analysis indicated that ancient gene duplication and functional divergence of the protein components of the complex occurred frequently during the evolutionary origin of the LECA from prokaryotes. We found that such duplications not only increased the complex's components， but also produced some new functional proteins involved in other nucleolar functions such as ribosome biogenesis and even some non-nucleolar (but nuclear) proteins participating in pre-mRNA splicing， implying the evolutionary emergence of the sub-nuclear compartment -- the nucleolus， has occurred in the LECA. Therefore， the LECA harbored not only complicated SSU processomes but even a nucleolus. Our analysis also revealed that gene duplication， innovation， and loss， caused further divergence of the complex during the divergence of eukaryotes.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如溴化汞硝酸亚汞氯化亚汞乙酸苯汞氯化钾汞 碘化汞钾硫氰酸汞硫酸亚汞氧化汞氯化汞碘化汞硝酸汞三氯氧磷三氯化磷碘甲烷二碘甲烷三碘甲烷三氟碘甲烷氘代碘甲烷碘乙烷1,2-二碘乙烷甲酸铷碘化铷溴化铷铬酸铷硫酸铷氟化铷硝酸铷氯化铷碳酸铷硫酸镱 碳酸镱氯化镱硝酸镱氧化镱等均有销售.欢迎订购

上一篇：西亚试剂：Systematic screen reveals new functional dynamics of histon
下一篇：西亚试剂:欧洲化工可以走出困境——Cefic总干事休伯特·曼德里一席谈