西亚试剂：CO2 exacerbates oxygen toxicity

发布时间：2025-06-26

CO2 exacerbates oxygen toxicity

Benjamin Ezraty1, Ma?alène Chabalier1, Adrien Ducret1, Etienne Maisonneuve1 & Sam Dukan1

Aix Marseille Université, Laboratoire de Chimie Bactérienne (UPR 9043), Institut de Microbiologie de la Méditerranée (IFR88), CNRS, 31, Chemin Joseph Aiguier, 13402 Marseille, France

Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO2 (concentration range studied: 40–1,000 p.p.m.) increases death rates due to H2O2 stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H2O2-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx? dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO2 concentration. Thus, CO2 exacerbates ROS toxicity by increasing oxidative cellular lesions.

Keywords:carbon dioxide, DNA, Fenton reaction, oxidative stress, mutagenesis

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购

上一篇：西亚试剂：The transcription factor Erg is essential for definitive he
下一篇：西亚试剂：A soma-to-germline transformation in long-lived Caenorhabdi