西亚试剂:Offspring from Oocytes Derived from in Vitro Primordial Ger

发布时间：2025-06-29

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

文献检索：DOI： 10.1126/science.1226889

Reconstitution of female germ cell development in vitro is a key challenge in reproductive biology and medicine. We show here that female (XX) embryonic stem cells and induced pluripotent stem cells in mice are induced into primordial germ cell–like cells (PGCLCs)， which， when aggregated with female gonadal somatic cells as reconstituted ovaries， undergo X-reactivation， imprint erasure， and cyst formation， and exhibit meiotic potential. Upon transplantation under mouse ovarian bursa， PGCLCs in the reconstituted ovaries mature into germinal vesicle-stage oocytes， which then contribute to fertile offspring after in vitro maturation and fertilization. Our culture system serves as a robust foundation for the investigation of key properties of female germ cells， including the acquisition of totipotency， and for the reconstitution of whole female germ cell development in vitro.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇氯甲基甲醚 等均有销售.欢迎订购

上一篇：3-氯丙烯制法/工艺
下一篇：西亚试剂：：Oligonucleotide Purification