西亚试剂：Microenvironmental reprogramming of thymic epithelial cells

发布时间：2025-08-24

Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells
Paola Bonfanti,Stéphanie Claudinot,Alessandro W. Amici,Alison Farley,C. Clare Blackburn& Yann Barrandon

The thymus develops from the third pharyngeal pouch of the anterior gut and provides the necessary environment for thymopoiesis (the process by which thymocytes differentiate into mature T lymphocytes) and the establishment and maintenance of self-tolerance1, 2, 3. It contains thymic epithelial cells (TECs) that form a complex three-dimensional network organized in cortical and medullary compartments, the organization of which is notably different from simple or stratified epithelia4. TECs have an essential role in the generation of self-tolerant thymocytes through expression of the autoimmune regulator Aire5, 6, but the mechanisms involved in the specification and maintenance of TECs remain unclear7, 8, 9. Despite the different embryological origins of thymus and skin (endodermal and ectodermal, respectively), some cells of the thymic medulla express stratified-epithelium markers10, 11, 12, interpreted as promiscuous gene expression. Here we show that the thymus of the rat contains a population of clonogenic TECs that can be extensively cultured while conserving the capacity to integrate in a thymic epithelial network and to express major histocompatibility complex class II (MHC II) molecules and Aire. These cells can irreversibly adopt the fate of hair follicle multipotent stem cells when exposed to an inductive skin microenvironment; this change in fate is correlated with robust changes in gene expression. Hence, microenvironmental cues are sufficient here to re-direct epithelial cell fate, allowing crossing of primitive germ layer boundaries and an increase in potency13.

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