西亚试剂:TRPA1 is essential for the vascular response to environment

发布时间：2025-08-26

TRPA1 is essential for the vascular response to environmental cold exposure

Aisah A. Aubdool, Rabea Graepel, Xenia Kodji, Khadija M. Alawi, Jennifer V. Bodkin, Salil Srivastava, Clive Gentry, Richard Heads, Andrew D. Grant, Elizabeth S. Fernandes, Stuart Bevan & Susan D. Brain

 

The cold-induced vascular response, consisting of vasoconstriction followed by vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this physiological reflex response is historic knowledge, the mechanisms involved are unclear. Here by using a murine model of local environmental cold exposure, we show that ​TRPA1 acts as a primary vascular cold sensor, as determined through ​TRPA1 pharmacological antagonism or gene deletion. The initial cold-induced vasoconstriction is mediated via ​TRPA1-dependent ​superoxide production that stimulates ​α2C-adrenoceptors and Rho-kinase-mediated MLC phosphorylation, downstream of ​TRPA1 activation. The subsequent restorative blood flow component is also dependent on ​TRPA1 activation being mediated by sensory nerve-derived dilator neuropeptides ​CGRP and ​substance P, and also ​nNOS-derived NO. The results allow a new understanding of the importance of ​TRPA1 in cold exposure and provide impetus for further research into developing therapeutic agents aimed at the local protection of the skin in disease and adverse climates.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇氯甲基甲醚 等均有销售.欢迎订购

上一篇：β-葡萄糖醛酸苷酶（小牛肝）制法/工艺
下一篇：西亚试剂：美国找到可突破血脑屏障分子