西亚试剂：Integrated biochemical and mechanical signals regulate mult

发布时间：2025-08-31

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions
Dong Li1,2, Jiaxi Zhou1,2, Lu Wang1,2, Myung Eun Shin1,2, Pei Su1,2, Xiaohua Lei5, Haibin Kuang5, Weixiang Guo5, Hong Yang1,2, Linzhao Cheng6, Tetsuya S. Tanaka1,3, Deborah E. Leckband4, Albert B. Reynolds7, Enkui Duan5, and Fei Wang1,2

1Institute for Genomic Biology, 2Department of Cell and Developmental Biology, 3Department of Animal Sciences, and 4Department of Chemical and Molecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801
5State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China
6Stem Cell Program, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205
7Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232

Human embryonic stem cells (ESCs [hESCs]) proliferate as colonies wherein individual cells are strongly adhered to one another. This architecture is linked to hESC self-renewal, pluripotency, and survival and depends on epithelial cadherin (E-cadherin), NMMIIA (nonmuscle myosin IIA), and p120-catenin. E-cadherin and p120-catenin work within a positive feedback loop that promotes localized accumulation of E-cadherin at intercellular junctions. NMMIIA stabilizes p120-catenin protein and controls E-cadherin–mediated intercellular adhesion. Perturbations of this signaling network disrupt colony formation, destabilize the transcriptional regulatory circuitry for pluripotency, and impair long-term survival of hESCs. Furthermore, depletion of E-cadherin markedly reduces the efficiency of reprogramming of human somatic cells to an ESC-like state. The feedback regulation and mechanical–biochemical integration provide mechanistic insights for the regulation of intercellular adhesion and cellular architecture in hESCs during long-term self-renewal. Our findings also contribute to the understanding of microenvironmental regulation of hESC identity and somatic reprogramming.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购

上一篇：我国生物基材料逐步走向工业规模化实际应用和产业化阶段
下一篇：2017中国清洁能源行业年会在北京举行