西亚试剂：In vivo selection of tumor-targeting RNA motifs

发布时间：2025-09-12

In vivo selection of tumor-targeting RNA motifs

Jing Mi, Yingmiao Liu, Zahid N Rabbani, Zhongguang Yang, Johannes H Urban, Bruce A Sullenger & Bryan M Clary

In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.

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