西亚试剂：Memory and modularity in cell-fate decision making

发布时间：2025-09-13

Thomas M. Norman，Nathan D. Lord，Johan Paulsson Richard Losick

Genetically identical cells sharing an environment can display markedly different phenotypes. It is often unclear how much of this variation derives from chance， external signals， or attempts by individual cells to exert autonomous phenotypic programs. By observing thousands of cells for hundreds of consecutive generations under constant conditions， we dissect the stochastic decision between a solitary， motile state and a chained， sessile state in Bacillus subtilis. We show that the motile state is ‘memoryless’， exhibiting no autonomous control over the time spent in the state. In contrast， the time spent as connected chains of cells is tightly controlled， enforcing coordination among related cells in the multicellular state. We show that the three-protein regulatory circuit governing the decision is modular， as initiation and maintenance of chaining are genetically separable functions. As stimulation of the same initiating pathway triggers biofilm formation， we argue that autonomous timing allows a trial commitment to multicellularity that external signals could extend.

 

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如诺卡氏菌液(-)-樟脑神经鞘磷脂,从牛脑所得 杨梅苷愈创奥IAPN-叔丁基苯硫腈氯化物4-溴苯基五氟化硫色胺盐酸盐4-溴噻吩-2-甲醛纤维素粉 7-(二甲基氨基)-4-三氟甲基香豆素邻硝基苯肼盐酸盐3,3'-二氨基联苯胺四盐酸盐水合物美伐他汀丁卡因阿卡明全氟辛基季胺碘化物布西拉明硫酸多粘菌素B益母草浸膏黄苓干膏 L-2,3-二氨基丙酸盐酸盐黄糊精EB替代品(GoldView)等均有销售.欢迎订购

上一篇：西亚试剂:溴吡斯的明
下一篇：西亚试剂：Early origins and evolution of microRNAs and Piwi-interacti