西亚试剂：The Mohawk homeobox gene is a critical regulator of tendon

发布时间：2025-09-14

The Mohawk homeobox gene is a critical regulator of tendon differentiation
Yoshiaki Itoa, Naoya Toriuchia, Teruhito Yoshitakaa, Hiroe Ueno-Kudoha, Tempei Satoa, Shigetoshi Yokoyamaa, Keiichiro Nishidab, Takayuki Akimotoc, Michiko Takahashia, Shigeru Miyakia, and Hiroshi Asaharaa,1

aDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan;
bDepartment of Human Morphology, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan; and
cLaboratory of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan

Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx ?/? mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx ?/? mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx ?/? tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

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