Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals

Rosa Lapalombella1, Yuh-Ying Yeh1, Liwen Wang2, Asha Ramanunni1, Sarwish Rafiq1, 3, Shruti Jha1, Justin Staubli1, 3, David M. Lucas1, 5, Rajeswaran Mani1, 4, Sarah E.M. Herman1, 3, Amy J. Johnson1, 5, Arletta Lozanski1, Leslie Andritsos1, Jeffrey Jones1, Joseph M. Flynn1, Brian Lannutti10, Peter Thompson11, Paul Algate12, Scott Stromatt12, David Jarjoura6, Xiaokui Mo6, Dasheng Wang5, Ching-Shih Chen1, 5, Gerard Lozanski7, Nyla A. Heerema7, Susheela Tridandapani8, Michael A. Freitas9, 13, Natarajan Muthusamy1, 4, 9, 13, ,   and John C. Byrd

Tetraspanins are commonly believed to act only as molecular facilitators, with no direct role in signal transduction. We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expressed on mature normal and transformed B cells, becomes tyrosine phosphorylated, associates with proximal signaling molecules, and initiates a cascade of events leading to apoptosis. Moreover, we have identified two tyrosine residues with opposing regulatory functions: one lies in the N-terminal domain of CD37 in a predicted ITIM-like motif and mediates SHP1-dependent death, whereas the second lies in a predicted ITAM motif in the C-terminal domain of CD37 and counteracts death signals by mediating phosphatidylinositol 3-kinase-dependent survival.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购