西亚试剂：Glucose and Weight Control in Mice with a Designed Ghrelin

发布时间：2025-05-15

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor
Brad P. Barnett1,2,*, Yousang Hwang1,*, Martin S. Taylor1,2,*, Henriette Kirchner3, Paul T. Pfluger3, Vincent Bernard2, Yu-yi Lin2,6, Erin M. Bowers1, Chandrani Mukherjee1, Woo-Jin Song4, Patti A. Longo5, Daniel J. Leahy5, Mehboob A. Hussain4, Matthias H. Tsch?p3, Jef D. Boeke2,? and Philip A. Cole1,??

1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Molecular Biology and Genetics and High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3Obesity Research Center, Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.
4Metabolism Division, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The biological activities of ghrelin require octanoylation of the peptide on Ser3, an unusual posttranslational modification that is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT). Here, we describe the design, synthesis, and characterization of GO-CoA-Tat, a peptide-based bisubstrate analog that antagonizes GOAT. GO-CoA-Tat potently inhibits GOAT in vitro, in cultured cells, and in mice. Intraperitoneal administration of GO-CoA-Tat improves glucose tolerance and reduces weight gain in wild-type mice but not in ghrelin-deficient mice, supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibition. In addition to serving as a research tool for mapping ghrelin actions, GO-CoA-Tat may help pave the way for clinical targeting of GOAT in metabolic diseases.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如汞乙酸汞氯化汞氧化汞碘化汞硫酸汞硝酸汞溴化汞硝酸亚汞氯化亚汞乙酸苯汞碘化汞钾硫氰酸汞氯化氨基汞三氯生三氯氧磷三氯乙烯水合氯醛三氯化磷三氯化钌三氯化钛三氯化铱三氯化铑三氯硫磷三氯乙烷三氯甲烷三氯卡班TCC1,3,5-三氯苯1,2,4-三氯苯1,2,3-三氯苯无水氯化铝三氯乙酸酐三氯乙酸钠碘甲烷二碘甲烷三碘甲烷 三氟碘甲烷硫酸二甲酯氯磺酸苯硫酚苯硫酚钠3-氨基苯硫酚2,6-二氯苯硫酚2,4-二氯苯硫酚2,5-二氯苯硫酚2-甲氧基苯硫酚2-氯乙醇 等均有销售.欢迎订购

上一篇：西亚试剂:日本发现白血病癌细胞增殖机制 或有助于开发治疗癌症药物
下一篇：西亚试剂：A cell type–restricted mRNA surveillance pathway triggered