Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M Reilly, Joshua Simon, Dara Leto, Shian-Huey Chiang, Louise Chang, Alan R Saltiel

Reduced energy expenditure in obesity may result from reduced sensitivity to sympathetic activation due to inflammation-generated signals in adipose tissue.

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